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In both studies, the NOEL was 750 mg / kg / day, corresponding to approximately 2.6 times the equivalent human dose of 350 mg four times daily, based on a comparison order soma cheap Newport News of the body surface.

The importance of these findings for human fertility order soma cheap Newport News is unknown. Animal studies indicate that carisoprodol crosses the placenta and causes adverse effects on order soma cheap Newport News fetal growthand postnatal survival. The major metabolite of carisoprodol, meprobamate, is an approved anxiolytic.

Retrospective, post-marketing studies do not show a consistent association between maternal consumption of meprobamate and an increased risk of birth defects in particular. Animal studies have not adequately evaluated the teratogenic effects of carisoprodol. There was no increased incidence of congenital malformations observed in lesDes reproduction studies in rats, rabbits and mice treated with meprobamate.

Retrospective, post-marketing studies of meprobamate during human pregnancy are equivocal for demonstrating an increased risk of birth defects following exposure during the first quarter. Among the studies that order soma cheap Newport News have shown an increased risk of malformations incompatible types. In animal studies, carisoprodol reduced fetal weights, weight gain after birth, and postnatal survival at maternal doses equivalent to 1 to 1.5 times the human dose (based on order soma cheap Newport News a comparison of body surface). Rats exposed to meprobamate in utero showed behavioral alterations that persist into adulthood.

For children exposed in utero to meprobamate, a study found no negative effect on the development of motor or mental health of IQ scores.

SOMA should be used during pregnancy only if the potential benefit justifies the risk to the fetus. No information on the effects of SOMA on the mother and fetus during labor. Very limited data in humans show order soma cheap Newport News that SOMA is present in breast milk and order soma cheap Newport News may reach concentrations two to four times the levels of maternal plasma. In one reported case, a breastfed baby receives about 4-6% of the maternal daily dose through breast milk and experienced no adverse effects. However, milk production was inadequate and that the baby was supplemented with formula.

In studies of lactation order soma cheap Newport News in mice, the survival of women and newborn pup weight at weaning was reduced. These data suggest that maternal use of SOMA can lead to the reduction of infant feeding order soma cheap Newport News or less effective (due to sedation) and / or decreased milk production.